Table 3 |
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|
Comparative analysis of studies examining expression of STAT3 and phosphorylated STAT3 in cervical precancer and cancerous lesions |
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|
Study (Year) |
Tissues |
Type of study |
Immunohistochemistry (% positivity) |
Immunoblotting (% positivity) |
STAT3 DNA Binding |
Correlation with HPV positivity |
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|
|
|
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|
Precancer (n) |
Cancer (n) |
STAT3 |
pSTAT3 (Y705) |
pSTAT3 (S727) |
STAT3 |
pSTAT3 (Y705) |
pSTAT3 (S727) |
||||
|
|
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|
Yang et al. (2005) |
56 |
- |
Retrospective |
ND |
ND |
42% (24/56)a |
ND |
ND |
ND |
ND |
ND |
|
Yang et al. (2006) |
56 |
- |
Retrospective |
39% (22/56)a |
ND |
ND |
ND |
ND |
ND |
ND |
ND |
|
Chen et al. (2007) |
- |
104 |
Retrospective |
ND |
24% (25/104)b |
23% (24/104)b |
ND |
ND |
ND |
ND |
ND |
|
Takemoto et al. (2009) |
- |
125 |
Retrospective |
ND |
57% (71/125)b |
ND |
ND |
ND |
ND |
ND |
ND |
|
Shukla et al. (present study) |
30 |
70 |
Prospective |
25% (5/20)a 71% (30/50)b |
20% (4/20)a 56% (28/50)b |
10% (2/20)a 40% (20/50)b |
40% (12/30)a 71% (50/70)b |
33% (10/30) a 57% (40/70) b |
33% (10/30) a 45% (32/70)b |
Yes |
Yes |
|
|
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|
aPrecancer tissues, bCancer tissues; ND - not determined. |
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|
Shukla et al. Molecular Cancer 2010 9:282 doi:10.1186/1476-4598-9-282 |
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