Open Access Research

Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection

Shirish Shukla1, Gauri Shishodia1, Sutapa Mahata1, Suresh Hedau1, Arvind Pandey1, Suresh Bhambhani2, Swaraj Batra3, Seemi F Basir4, Bhudev C Das1,5 and Alok C Bharti1*

1 Division of Molecular Oncology, Institute of Cytology & Preventive Oncology, I-7, Sector-39, NOIDA, U.P.-201301, India

2 Division of Cytopathology, Institute of Cytology & Preventive Oncology, I-7, Sector-39, NOIDA, U.P.-201301, India

3 Department of Gynae and Obstetrics, Lok Nayak Hospital, New Delhi, 110002, India

4 Department of Biosciences, Jamia Millia Islamia, New Delhi, 110025, India

5 Dr. B.R. Ambedakar Centre for Biomedical Research, University of Delhi, New Delhi, 110029, India

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Molecular Cancer 2010, 9:282 doi:10.1186/1476-4598-9-282

Published: 27 October 2010

Additional files

Additional file 1:

Table S1. Expression of STAT3 and phosphorylated STAT3 [pSTAT3(Y705) and pSTAT3(S727)] in normal, pre-cancer and cancer lesions of the uterine cervix as observed by immunoblotting.

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Additional file 2:

Table S2. Immunohistochemical analysis of STAT3 and phosphorylated STAT3 [pSTAT3 (Y705) and pSTAT3 (S727)] expression in normal, pre-cancer and cancer lesions of the uterine cervix.

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