Research
Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition
1 Dept. Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
2 Dept. Immunology and Oncology, Centro Nacional de Biotecnología, Madrid, Spain
3 Dept. Biochemistry, School of Medicine, Universidad Autónoma-Instituto de Investigaciones Biomédicas "Alberto Sols", IdiPaz, Madrid, Spain
4 Dept. Animal Surgery and Medicine, School of Veterinary, Complutense University, Madrid, Spain
5 Servicio de Anatomía Patológica, Hospital Virgen del Rocío, Seville, Spain
6 Current Address: MMC, Dept. Pathology, University of Cambridge, United Kingdom; CC, Dept. Life Sciences, The Open University, Milton Keynes, UK
Molecular Cancer 2010, 9:196 doi:10.1186/1476-4598-9-196
Published: 22 July 2010Additional files
Additional file 1:
Figures S1-S5. Supplemental Figure 1: MMTV-neu mice spontaneously develop breast tumors and lung metastases. Supplemental Figure 2: Cannabinoids inhibit breast tumor growth in vivo Supplemental Figure 3: MMTV-neu-derived tumors express cannabinoid receptors Supplemental Figure 4: Cannabinoids modulate the expression of MMP2 and MMP9 Supplemental Figure 5: Human ErbB2-positive breast cancer cell lines are sensitive to cannabinoids
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