Table 1

Well-differentiated and poorly differentiated HCC cell lines according to hepatocyte lineage, epithelial and mesenchymal markers, and in vitro motility and invasiveness assays

Cell Lines

Fetal Hepatocyte Marker

Epithelial & Hepatocyte Markers

Mesenchymal markers

Motility

Invasiveness


AFP

HNF4a

HNF1a

E-cadherin

vimentin

slug

Snail

Twist-1

Twist-2


Well-differentiated


HepG2

High

High

High

Low

(-)

Low

Low

Low

High

Low

Low [14]


Huh7

High

High

High

High

Low

(±)

Low

Low

(-)

Low

Low [14]


Hep3B

High

High

High

High

Low

High

Low

(-)

(-)

Low

Low ([74]


Hep40

High

High

High

Low

High

(-)

High

High

Low

Low

n.t.


Poorly differentiated


SNU398

(-)

(-)

(-)

Low

High

Low

High

High

High

Low

n.t.


SNU475

(±)

(-)

(-)

(-)

High

High

High

High

Low

High

n.t.


SNU449

(-)

Low

(-)

(±)

High

Low

Low

High

High

High

n.t.


SNU387

(-)

(-)

(-)

(-)

Low

High

High

(-)

(±)

n.t.

n.t.


FOCUS

(-)

(-)

(-)

Low

High

Low

(-)

(-)

Low

n.t.

n.t.


Mahlavu

(-)

(-)

(-)

(±)

High

Low

(-)

High

Low

High

High [74]


SNU182

(-)

(-)

(±)

High

high

High

High

High

High

High

n.t.


(-); not detected; ±; traces; n.t.; not tested.

Yuzugullu et al. Molecular Cancer 2009 8:90   doi:10.1186/1476-4598-8-90

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