Table 1 |
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|
Well-differentiated and poorly differentiated HCC cell lines according to hepatocyte lineage, epithelial and mesenchymal markers, and in vitro motility and invasiveness assays |
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|
Cell Lines |
Fetal Hepatocyte Marker |
Epithelial & Hepatocyte Markers |
Mesenchymal markers |
Motility |
Invasiveness |
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|
|
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|
AFP |
HNF4a |
HNF1a |
E-cadherin |
vimentin |
slug |
Snail |
Twist-1 |
Twist-2 |
|||
|
|
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|
Well-differentiated |
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|
|
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|
HepG2 |
High |
High |
High |
Low |
(-) |
Low |
Low |
Low |
High |
Low |
Low [14] |
|
|
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|
Huh7 |
High |
High |
High |
High |
Low |
(±) |
Low |
Low |
(-) |
Low |
Low [14] |
|
|
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|
Hep3B |
High |
High |
High |
High |
Low |
High |
Low |
(-) |
(-) |
Low |
Low ([74] |
|
|
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|
Hep40 |
High |
High |
High |
Low |
High |
(-) |
High |
High |
Low |
Low |
n.t. |
|
|
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|
Poorly differentiated |
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|
|
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|
SNU398 |
(-) |
(-) |
(-) |
Low |
High |
Low |
High |
High |
High |
Low |
n.t. |
|
|
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|
SNU475 |
(±) |
(-) |
(-) |
(-) |
High |
High |
High |
High |
Low |
High |
n.t. |
|
|
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|
SNU449 |
(-) |
Low |
(-) |
(±) |
High |
Low |
Low |
High |
High |
High |
n.t. |
|
|
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|
SNU387 |
(-) |
(-) |
(-) |
(-) |
Low |
High |
High |
(-) |
(±) |
n.t. |
n.t. |
|
|
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|
FOCUS |
(-) |
(-) |
(-) |
Low |
High |
Low |
(-) |
(-) |
Low |
n.t. |
n.t. |
|
|
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|
Mahlavu |
(-) |
(-) |
(-) |
(±) |
High |
Low |
(-) |
High |
Low |
High |
High [74] |
|
|
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|
SNU182 |
(-) |
(-) |
(±) |
High |
high |
High |
High |
High |
High |
High |
n.t. |
|
|
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|
(-); not detected; ±; traces; n.t.; not tested. |
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|
Yuzugullu et al. Molecular Cancer 2009 8:90 doi:10.1186/1476-4598-8-90 |
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