Activation of JNK is enhanced in HCC samples. (A). Tissue microarray with paired human HCC and the adjacent non-cancerous tissue (ANC) was stained with pJNK antibody. The inserted panels show a typical immunostaining pattern of pJNK in a single HCC cell and non-cancerous cell, respectively; (B). Enhanced pJNK staining in the small foci of necrosis was indicated by the red arrows in HCC tissue. (C). JNK1 specific kinase activity assay in 4 HCC tissue samples (T) paired with the non-cancerous liver tissues (N).
Chang et al. Molecular Cancer 2009 8:64 doi:10.1186/1476-4598-8-64