Figure 2.

Monitorization of hepatic tumors by BLI and US. A.-MC38Luc1 cells were injected in the liver of C57BL/6 mice (n = 20), and tumor progression was evaluated weekly by either BLI (bottom pictures), US (middle pictures) or direct tumor measurement through laparotomy or necropsy (upper pictures). Margins of tumors are indicated with a dotted line in the US images. B.-Example of lung metastases secondary to the hepatic lesions 4 weeks after cell implantation in the liver. Detection by BLI (bottom picture) and confirmation after necropsy (upper picture).