Molecular Cancer

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An integrative model for recurrence in ovarian cancer

Alexandros Laios1, Sharon A O'Toole1*, Richard Flavin2, Cara Martin2, Martina Ring2, Noreen Gleeson1, Tom D'Arcy1, Eamonn PJ McGuinness1, Orla Sheils2, Brian L Sheppard1 and John J O' Leary2

Author Affiliations

1 Department of Obstetrics and Gynaecology, Trinity College Dublin, Trinity Centre for Health Sciences, St. James's Hospital, Dublin 8, Ireland

2 Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James's Hospital, Dublin 8, Ireland

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Molecular Cancer 2008, 7:8 doi:10.1186/1476-4598-7-8

Published: 22 January 2008

First paragraph (this article has no abstract)

Ovarian cancer is one of the commonest cancers in women and the leading cause of death from gynaecological malignancy in the western world. About 205,000 cases of ovarian cancer are diagnosed worldwide each year [1]. It accounts for 3% of female cancers in Ireland with over 350 new cases each year [2]. Marked heterogeneity is a hallmark of the disease, not only in tumor histotype and grade but also in response to chemotherapy and overall prognosis [3]. Over 90% of cases arise from the surface epithelium. Serous adenocarcinomas are the commonest and account for 40%–50% of malignant neoplasms [4].