An integrative model for recurrence in ovarian cancer

doi:10.1186/1476-4598-7-8

Molecular Cancer
Volume 7

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Laios A
O'Toole SA
Flavin R
Martin C
Ring M
Gleeson N
D'Arcy T
McGuinness EP
Sheils O
Sheppard BL
O' Leary JJ

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Laios A
O'Toole SA
Flavin R
Martin C
Ring M
Gleeson N
D'Arcy T
McGuinness EP
Sheils O
Sheppard BL
O' Leary JJ
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An integrative model for recurrence in ovarian cancer

Alexandros Laios¹ , Sharon A O'Toole¹ , Richard Flavin² , Cara Martin² , Martina Ring² , Noreen Gleeson¹ , Tom D'Arcy¹ , Eamonn PJ McGuinness¹ , Orla Sheils² , Brian L Sheppard¹ and John J O' Leary²

¹Department of Obstetrics and Gynaecology, Trinity College Dublin, Trinity Centre for Health Sciences, St. James's Hospital, Dublin 8, Ireland

²Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James's Hospital, Dublin 8, Ireland

author email corresponding author email

Molecular Cancer 2008, 7:8doi:10.1186/1476-4598-7-8


Published:	22 January 2008

First paragraph (this article has no abstract)

Ovarian cancer is one of the commonest cancers in women and the leading cause of death from gynaecological malignancy in the western world. About 205,000 cases of ovarian cancer are diagnosed worldwide each year [1]. It accounts for 3% of female cancers in Ireland with over 350 new cases each year [2]. Marked heterogeneity is a hallmark of the disease, not only in tumor histotype and grade but also in response to chemotherapy and overall prognosis [3]. Over 90% of cases arise from the surface epithelium. Serous adenocarcinomas are the commonest and account for 40%–50% of malignant neoplasms [4].