Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells

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Pinella Buongiorno¹^,2^,3 , Vaijayanti V Pethe¹^,2 , George S Charames¹^,2^,3 , Susmita Esufali¹^,2^,3 and Bharati Bapat¹^,2^,3

¹Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5T 3L9, Canada

²Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada

³Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada

author email corresponding author email

Molecular Cancer 2008, 7:73doi:10.1186/1476-4598-7-73


Published:	30 September 2008

Additional file 1:

Supplementary Information. This contains the Supplementary Methods information and the Supplementary figure legends.

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Additional file 2:

Supplementary figure 1. Active Rac1 binds to the concensus TBE in vitro as shown by electrophoretic mobility shift assay (EMSA).

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Additional file 3:

Supplementary figure 2. Active Rac1 enhances transcription from Wnt-responsive promoters.

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Additional file 4:

Supplementary figure 3. Wnt3a-CM stimulates the canonical Wnt pathway in 293T cells.

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