EPLIN-α expression on cell migration as analysed by ECIS. A: wounding assays. Cells were first wounded at 6 v for 30 sec. The impedance change was shown. Electrode – A1: MDA-MB231wt, A2: MDA-MB231pEF/His, A3: MDA-MB231EPLINexp3, A4: MDA-MB231EPLINexp4. The breast cancer cells which over-expressed EPLIN-α showed a markedly reduced migration. B and C: ECIS RbA modelling of cell motility indicated a significant reduction of motility in EPLIN-α transfected cells as shown by resistance in B and capacitance in C. * p < 0.01 vs MDA-MB231wt and MDA-MB231pEF/His.
Jiang et al. Molecular Cancer 2008 7:71 doi:10.1186/1476-4598-7-71