|
Clinicopathological and genetic characteristics of Omani CRC cases. |
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| Omani |
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|
|
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| All |
non-MSI-H |
MSI-H |
Odds Ratio |
P |
|
|
|
|||||
| Number of patients |
61 |
53 (87)a |
8 (13)a |
||
| Mean Age |
52.7+13.6 - |
53.1+12.8 - |
51.5+19.2 - |
0.76 |
|
| Gender |
0.37 |
||||
| Female |
24 (39) |
22 (42) |
2 (25) |
1 |
|
| Male |
37 (61) |
31(58) |
6 (75) |
2.12(0.39–11.55) |
|
| Site |
61 |
0.75 |
|||
| Distal |
51 (84) |
44(83) |
7(87) |
1 |
|
| Proximal |
10 (16) |
9(17) |
1(13) |
1.43(0.16–13.11) |
|
| Mucin Production |
61 |
0.44 |
|||
| None |
47 (77) |
42(78) |
5 (63) |
1 |
|
| < 50% |
14(23) |
11 (20) |
3(37) |
2.3(0.47–11.10) |
|
| > 50% |
0 |
0 |
0 |
NA |
|
| Differentiation |
60 |
0.44 |
|||
| Well |
7 (12) |
7 (14) |
0 |
NA |
|
| Moderate |
49(82) |
43 (81) |
6(86) |
1 |
|
| Poor |
4 (6) |
3 (6) |
1 (14) |
2.39(0.21–26.84) |
|
| Stage |
61 |
0.28 |
|||
| Stage 1 |
1 (2) |
1 (2) |
0 |
NA |
|
| Stage 2 |
20 (33) |
15 (28) |
5 (62) |
1 |
|
| Stage 3 |
31 (50) |
29 (55) |
2 (25) |
0.21(0.02–1.50) |
|
| Stage 4 |
9 (15) |
8 (15) |
1 (13) |
0.38(0.01–4.41) |
|
| BRAF |
59 |
0.62 |
|||
| Wild type |
48 (81) |
42 (82) |
6 (75) |
1 |
|
| V600E |
11 (19) |
9 (18) |
2 (25) |
1.56(0.27–9.0) |
|
| hMLH1 methylation (MSP) |
49 |
0.47 |
|||
| Unmethylation |
8 (16) |
6(14.6) |
2 (25) |
1 |
|
| Methylation |
41 (84) |
35 (85.4) |
6 (75) |
0.51(0.08–3.17) |
|
| p16 methylation (MSP) |
44 |
0.09 |
|||
| Unmethylation |
27(62) |
20 (56) |
7 (88) |
1 |
|
| Methylation |
17 (38) |
16 (44) |
1 (12) |
0.18(0.02–1.61) |
|
| hMLH1 expression by IHC |
61 |
0.68 |
|||
| Normal |
42 (69) |
37(70) |
5 (62) |
1 |
|
| Negative |
19 (32) |
16 (30) |
3(38) |
1.39(0.29–6.67) |
|
| hMSH2 expression by IHC |
61 |
0.63 |
|||
| Normal |
56 (92) |
49 (92) |
7(87) |
1 |
|
| Negative |
5 (8) |
4 (8) |
1(13) |
1.75(0.17–16.67) |
|
|
Parentheses indicate percentages: All values are based on column except a based on row. MSP = methylation-specific PCR; IHC = immunohistochemistry | |||||
Brim et al. Molecular Cancer 2008 7:68 doi:10.1186/1476-4598-7-68 |
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