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Over expressed genes as a consequence of chromosome 5p gain in cervical cancer |
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| Gene |
Description |
Function |
Role in cancer |
Average fold change# |
|
|
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| OSMR |
Oncostatin M receptor |
Signal transduction |
[31] |
3.1 |
| BASP1 |
Brain abundant, membrane attached signal protein 1 |
DNA binding |
- |
6.0 |
| C5orf28 |
Chromosome 5 open reading frame 28 |
Not known |
- |
2.9 |
| TRIP13 |
Thyroid hormone receptor interactor 13 |
HPV16 E1 protein binding protein |
[24] |
5.0 |
| NNT |
Nicotinamide nucleotide transhydrogenase |
Detoxification of ROS |
- |
3.7 |
| TARS |
Threonyl-tRNA synthetase |
Aminoacylation of tRNA |
- |
3.2 |
| PAIP1 |
Polyadenylate-binding protein-interacting protein 1 |
Translation activator activity |
- |
2.3 |
| SDHA |
Succinate dehydrogenase complex, subunit A, flavoprotein |
Oxidative phosphorylation |
- |
3.4 |
| NDUFS6 |
NADH dehydrogenase (ubiquinone) Fe-S protein 6 |
Oxidative phosphorylation |
- |
2.3 |
| BRD9 |
Bromodomain containing 9 |
Nucleic acid binding |
- |
2.2 |
| FASTKD3 |
FAST kinase domains 3 |
Unknown |
- |
2.4 |
| RAD1 |
RAD1 homolog |
DNA repair, cell cycle check point |
- |
3.2 |
| BXDC2 |
Brix domain containing 2 |
Ribosomal biosynthesis |
- |
2.6 |
| SKP2 |
S-phase kinase-associated protein 2 |
Mitotic check point |
[33] |
3.6 |
| C5orf22 |
Chromosome 5 open reading frame 22 |
Unknown |
- |
3.0 |
| POLS |
Polymerase (DNA directed) sigma |
DNA repair |
- |
2.8 |
| RNASEN |
Ribonuclease III, nuclear |
miRNA processing |
[27] |
2.8 |
|
# Fold-change is calculated based on comparison between normal cervical squamous epithelium and tumors with Chr5p gain | ||||
Scotto et al. Molecular Cancer 2008 7:58 doi:10.1186/1476-4598-7-58 |
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