Table 2

Differential effect of selected metabolites on the growth of Jurkat cells and normal lymphoblasts


Jurkat
 Lymphoblasts


Metabolite
 c [μM]1
 Growth [%]
 SEM [%]2
 p-value
 Growth [%]
 SEM [%]2
 p-value
Menaquinone
 100
 18.2
 0.36
 4.5 × 10-7
 89.7
 8.5
 0.38

50
 40.3
 1.15
 2.0 × 10-7
 109.9
 5.8
 0.23
Dehydroepiandrosterone
 100
 23.8
 0.18
 2.1 × 10-6
 94.9
 0.6
 0.15

50
 83.2
 0.23
 2.0 × 10-3
 130.8
 6.9
 0.020
Se-Seleno-L-methionine
 100
 41.0
 0.67
 1.0 × 10-7
 79.3
 5.8
 0.028

50
 53.2
 0.85
 2.0 × 10-3
 84.2
 1.4
 2.7 × 10-4
5,6-dimethylbenzimidazole
 100
 80.4
 3.56
 6.2 × 10-3
 82.9
 4.4
 0.023

50
 87.8
 1.41
 0.021
 97.4
 1.9
 0.037

1 Metabolite concentration.

2 Standard error of the mean.

3 Statistical significance of the observed effect on cell growth, as evaluated by two-tailed t-tests.

Arakaki et al. Molecular Cancer 2008 7:57   doi:10.1186/1476-4598-7-57