Figure 1.

Diagram representing the rationale of CoMet. (A) The intracellular level of a metabolite X is predicted to be increased in cancer cells when enzymes that produce X are upregulated and/or enzymes that consume X are downregulated in cancer cells. (B) The intracellular level of a metabolite X is predicted to be decreased in cancer cells when enzymes that produce X are downregulated and/or enzymes that consume X are upregulated in cancer cells. See Material and Methods for a complete description of the rules.