Figure 6.

Increased expression of ER stress marker CHOP by CXB, UMC, and DMC in tumor cells with high or no COX-2 expression. MIA-PaCa-2 (COX-2 negative) and Bx-PC-3 (high COX-2 expression) pancreatic carcinoma cells were treated with the indicated concentrations of CXB, UMC, or DMC for 18 hours and cell lysates were analyzed by Western blot with specific antibodies to CHOP (a pro-apoptotic ER stress indicator protein) and actin (to verify equal loading in each lane).