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List of top dysregulated mirnas and their predicted gene targets. |
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| MiRNA |
Fold change |
Expression in recuurent vs Primary |
MiRGen |
Transcriptome study13 |
|
|
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| miR-223 |
11.35571231 |
Upregulated |
FGFR2, EGF, S100A3, KRAS, TGFB2, IFNB1, SPINK5, E2F1 |
SEPTIN6, MMP9, USF2 |
| miR-9 |
3.886456405 |
Downregulated |
FGF18, FGF10, BCL2, BCL6, BRAF, CLDN14, CLDN6, SEPTIN10 |
ZNF, PVRL2, LASS4, BCL2, CLDN, FGF |
|
These represent genes predicted by MiRGen well characterised in ovarian carcinogenesis and also genes identified in an earlier study performed by our group [13]. | ||||
Laios et al. Molecular Cancer 2008 7:35 doi:10.1186/1476-4598-7-35 |
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