Figure 1.

Flow chart of our study design. miRNA profiling was performed using TaqMan PCR in a homogenous set of 3 primary advanced and 3 recurrent serous papillary ovarian adenocarcinomas from different patients. Selected miRNA targets (n = 2) were examined in two independent sets of primary and recurrent fresh frozen (n = 18) and FFPE serous papillary adenocarcinomas (n = 22). We also attempted to determine whether components of the miRNA processing machinery (Dicer and Drosha) are responsible for miRNA dysregulation in recurrent ovarian cancer.