|
Summary of putative and potential functions of LASP-1 and LASP-2 |
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| protein |
localization |
putative and potential function |
reference(s) |
|
|
|||
| LASP-1 |
focal contacts |
signal transducer for IGF-1 |
[49] |
| zyxin recruiting protein |
[38, 39] |
||
| modulator of migration and pseudopodial elongation |
[19, 25, 38, 39, 46, 47] |
||
| interaction partner for cytoskeletal organisation |
[7, 8, 10, 11, 13, 14, 26, 27] |
||
| stabilisation of actin filament bundles |
[11] |
||
| modulator of active HCl secretion in gastric parietal cells |
[17, 18, 20, 21, 70] |
||
| nucleus |
modulator of proliferation in concert with other proteins |
[25, 38, 39] |
|
| cell-cycle-control |
[26, 38, 39] |
||
| (transcription factor) |
[6, 25] |
||
| postsynaptic/CNS |
axonal growth and differentiation/structural protein/autism linked gene |
[40, 42] |
|
| Z-discs/A-bands |
structural protein (possibly function in myofilament stabilization and assembly) |
[12] |
|
| LASP-2 |
focal contacts |
interaction partner for cytoskeletal organisation |
[27, 30] |
| stabilisation of actin filament bundles |
[11] |
||
| Z-discs |
structural protein/myofilament stabilization and assembly |
[12, 37] |
|
| CNS |
unclear/structural protein |
[30] |
|
Grunewald and Butt Molecular Cancer 2008 7:31 doi:10.1186/1476-4598-7-31 |
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