Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cγ at the centrosome

Hélène Lelièvre¹^,2 , Véronique Chevrier¹ , Anne-Marie Tassin³ and Daniel Birnbaum¹

¹Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm, Institut Paoli-Calmettes, Marseille, France

²FRE CNRS 2737, Faculté de Pharmacie, Marseille, France

³Institut Curie, UMR146 CNRS, Orsay, France

author email corresponding author email

Molecular Cancer 2008, 7:30doi:10.1186/1476-4598-7-30


Published:	15 April 2008

Additional files

Additional files 1:

CEP110-FGFR1 localizes at the centrosome and provides a centrosomal pYXXM motif at the centrosome. Ba/F3 cells stably expressing CEP110-FGFR1 are stained with anti-γ tubulin antibody (green, b,e,h) to localize the centrosome. Costaining with anti-FGFR1, anti-pYXXM and anti-p85 antibodies (red, a,d,g) allows to localize respectively CEP110-FGFR1, phosphotyrosines in a YXXM motif and p85 PI3K in the cells. Scale bar, 5 μm.

Format: PDF Size: 668KB Download file

This file can be viewed with: Adobe Acrobat Reader