Additional file 2.

Heterogeneity of Brca1 tumors. (A) H&E staining of original Brca1 tumors shows three representative types of morphology. A1 tumor shows features of adenosquamous carcinoma composed of sheets of squamous epithelial cells with eosinophilic cytoplasm and large leptochromatic nuclei. Some cells also form clusters of irregular glands. Several areas have whorls and clusters of spindle-shaped tumor cells suggestive of EMT. RP tumor shows features of, glandular carcinoma with no evidence of EMT. RA tumor has features of squamous nonkeratinizing Carcinoma. This tumor also does not show evidence of EMT. (B) Immunofluorescent detection of vimentin (red) and SMA (green) (right panels) shows mesenchymal features (vimentin) in tumor 0_A1. SMA stains fibroblasts only and not tumor cells, and is used here as control.

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Wright et al. Molecular Cancer 2008 7:29   doi:10.1186/1476-4598-7-29