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Molecular analysis reveals heterogeneity of mouse mammary tumors conditionally mutant for Brca1

Mollie H Wright, Ana I Robles†, Jason I Herschkowitz†, Melinda G Hollingshead, Miriam R Anver, Charles M Perou and Lyuba Varticovski*

Molecular Cancer 2008, 7:29 doi:10.1186/1476-4598-7-29

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Brca1 breast tumors contain distinct CD44+/CD24- and CD133+ cells with cancer stem cell characteristics

Mollie H Wright, Anna Calcagno, Crystal D Salcido, Marisa D Carlson, Suresh V Ambudkar, Lyuba Varticovski Breast Cancer Research 2008, 10:R10 (1 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Brca1-deficient mouse mammary tumours harbour heterogeneous cancer stem cell populations and CD44+/24- cells also identify human breast cancer stem cells; spheroid-forming assay may allow rapid screening of tumours for stem cell enrichment.

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