|
The table summarizes the effects of hypoxia and/or etoposide on the abundance and the activity of 10 transcription factors. |
||||||
| N |
Ne |
H |
He |
|||
|
|
||||||
| p53 |
TFChipMAPK |
++ |
+++ |
+ |
++ |
|
| Trans-AM |
++ |
+++ |
+ |
++ |
||
| prot level |
++ (cyt) |
+++ (cyt+nuc) |
+ (cyt) |
++ (cyt+nuc) |
||
| P-p53 |
prot level (nuc) |
0 |
+++ |
+ |
+++ |
|
| reporter system |
++ |
+++ |
+ |
++ |
||
| AP-1 |
c-jun |
Trans-AM |
+ |
+ |
++ |
+++ |
| prot level (nuc) |
+ |
+++ |
++ |
+++ |
||
| P-c-jun |
TFChipMAPK |
+ |
+ |
++ |
+++ |
|
| prot level (nuc) |
+ |
++ |
+ |
++ |
||
| c-fos |
Trans-AM |
+ |
+++ |
++ |
+++ |
|
| prot level (cyt+nuc) |
+ |
+++ |
++ |
+++ |
||
| reporter system |
+ |
+ |
++ |
+++ |
||
| P-Elk-1 |
TFChipMAPK |
++ |
++ |
+ |
++ |
|
| Trans-AM |
++ |
++ |
+ |
+ |
||
| prot level (nuc) |
+ |
+ |
+ |
+ |
||
| CREB/ATF2 |
P-ATF-2 |
TFChipMAPK |
++ |
+ |
++ |
++ |
| prot level (cyt+nuc) |
+ |
+ |
+ |
++ |
||
| P-CREB |
Trans-AM |
+ |
+ |
+ |
+ |
|
| prot level (cyt+nuc) |
++ |
++ |
+ |
+ |
||
| reporter system |
+ |
+ |
+++ |
+ |
||
| MEF-2 |
TFChipMAPK |
++ |
++ |
+ |
+ |
|
| prot level |
+ (cyt+nuc) |
+++ (nuc) |
++ (cyt+nuc) |
+ (nuc) |
||
| c-myc |
TFChipMAPK |
++ |
0 |
+ |
0 |
|
| Trans-AM |
+++ |
++ |
+ |
0 |
||
| prot level (nuc) |
+++ |
+ |
++ |
+ |
||
| reporter system |
++ |
0 |
+ |
0 |
||
| STAT-1 |
TFChipMAPK |
0 |
0 |
0 |
+ |
|
| prot level |
+ (cyt) |
+ (cyt) |
+ (cyt) |
+++ (cyt+nuc) |
||
| NFATc1 |
TFChipMAPK |
0 |
0 |
0 |
0 |
|
| NF-kB |
c-rel |
prot level (cyt+nuc) |
++ |
++ |
++ |
++ |
| p50 |
prot level (cyt+nuc) |
+++ |
++ |
+ |
++ |
|
| p65 |
Trans-AM |
++ |
+++ |
+ |
+ |
|
| prot level (cyt) |
+ |
+ |
++ |
+ |
||
| reporter system |
+ |
++ |
+ |
++ |
||
| HIF-1 |
HIF-1α |
prot level (nuc) |
0 |
0 |
++ |
++ |
| Trans-AM |
+ |
+ |
+++ |
+++ |
||
| reporter system |
+ |
+ |
+++ |
+++ |
||
|
Cyt: cytosolic, nuc: nuclear, 0: not present or no activity. | ||||||
Sermeus et al. Molecular Cancer 2008 7:27 doi:10.1186/1476-4598-7-27 |
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