|
Gene expression profiling in HepG2 cells incubated with or without etoposide under normoxic or hypoxic conditions. |
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| N |
Ne |
H |
He |
|
|
|
||||
| BIRC3 |
1 |
2.99 |
1.53 |
2.31 |
| CLK1 |
1 |
2.77 |
2.28 |
4.03 |
| GADD45A |
1 |
4.32 |
1.47 |
3.54 |
| IGF2 |
1 |
2.67 |
1.59 |
1.57 |
| IGFBP4 |
1 |
4.35 |
1.77 |
2.39 |
| MCL1 |
1 |
3.44 |
3.92 |
5.27 |
| ALDOA |
1 |
1.00 |
1.43 |
1.59 |
| BAG1 |
1 |
2.07 |
1.37 |
2.16 |
| BIRC2 |
1 |
2.42 |
1.51 |
2.36 |
| BIRC4 |
1 |
1.25 |
1.69 |
1.43 |
| BNIP3 |
1 |
1.19 |
3.97 |
4.25 |
| ING |
1 |
1.48 |
1.83 |
1.97 |
| JUN |
1 |
1.66 |
2.33 |
3.28 |
| MAP2K1 |
1 |
1.38 |
2.16 |
2.05 |
| TANK |
1 |
1.77 |
1.34 |
1.60 |
| BAX |
1 |
2.45 |
0.88 |
1.44 |
| IGFBP2 |
1 |
1.83 |
1.21 |
1.30 |
| MDM2 |
1 |
4.75 |
1.44 |
2.47 |
| TNFRSF6 |
1 |
5.70 |
0.69 |
5.11 |
| CASP1 |
1 |
2.84 |
1.00 |
1.71 |
| GAPD |
1 |
1.13 |
1.43 |
1.68 |
| K-ALPHA-1 |
1 |
1.03 |
0.78 |
0.73 |
| RPS9 |
1 |
1.30 |
1.19 |
1.48 |
| CDK7 |
1 |
1.60 |
1.60 |
1.52 |
| NFKB1 |
1 |
1.27 |
1.40 |
1.25 |
| BCL2A1 |
1 |
2.01 |
0.85 |
1.27 |
| CDKN1C |
1 |
1.45 |
1.06 |
0.90 |
| CDKN2B |
1 |
1.64 |
0.98 |
0.81 |
| MAPK12 |
1 |
1.96 |
1.10 |
1.06 |
| RBL2 |
1 |
1.88 |
1.03 |
0.99 |
| RBP1 |
1 |
2.05 |
1.01 |
1.16 |
| RIPK1 |
1 |
1.58 |
0.87 |
1.00 |
| TP53 |
1 |
1.82 |
0.68 |
0.85 |
| TP73 |
1 |
1.62 |
1.06 |
0.94 |
| YWHAZ |
1 |
2.62 |
0.82 |
0.81 |
| BIRC5 |
1 |
1.07 |
0.68 |
0.66 |
| CDC25C |
1 |
2.17 |
0.60 |
0.59 |
| CDK2 |
1 |
1.14 |
0.73 |
0.76 |
| MAPK9 |
1 |
1.15 |
0.76 |
0.67 |
| TFDP1 |
1 |
1.23 |
0.69 |
0.63 |
| GSR |
1 |
0.72 |
0.92 |
0.60 |
| GSA |
1 |
0.51 |
0.67 |
0.69 |
| BID |
1 |
1.50 |
0.83 |
1.06 |
| BIK |
1 |
2.09 |
0.63 |
0.92 |
| CDK9 |
1 |
1.48 |
0.75 |
0.72 |
| CLU |
1 |
1.54 |
0.81 |
1.09 |
| BclX |
1 |
1.85 |
1.11 |
0.81 |
| CASP2 |
1 |
1.12 |
0.83 |
0.81 |
| CDK4 |
1 |
0.72 |
0.98 |
0.74 |
| CDK5R1 |
1 |
1.43 |
0.87 |
0.75 |
| CDK6 |
1 |
1.18 |
1.30 |
0.52 |
| CSE1L |
1 |
1.05 |
1.01 |
0.71 |
| GRB2 |
1 |
1.31 |
0.83 |
0.72 |
| IGF1R |
1 |
1.26 |
1.10 |
0.66 |
| LTB |
1 |
1.38 |
0.97 |
0.82 |
| PLK |
1 |
1.14 |
0.81 |
0.46 |
| TNFSF7 |
1 |
1.50 |
1.00 |
0.74 |
| TRAF3 |
1 |
1.40 |
0.89 |
0.76 |
| BAK 1 |
1 |
3.42 |
0.75 |
2.13 |
| CDKN1A |
1 |
3.02 |
0.52 |
1.64 |
| GPX1 |
1 |
2.88 |
0.69 |
1.43 |
| CDC2 |
1 |
3.22 |
0.74 |
0.83 |
| PCNA |
1 |
2.23 |
0.62 |
1.68 |
| AKT2 |
1 |
1.55 |
1.00 |
0.78 |
| E2F5 |
1 |
1.20 |
1.90 |
0.61 |
|
Cells were incubated under normoxic (N) or hypoxic (H) conditions with or without etoposide (e, 50 μM) for 16 hours before RNA extraction, reverse-transcription and cDNA hybridization, as described in Materials and Methods. Each value is the average of three ratio values calculated from three independent experiments. Mean ratios indicate a fold-increase or decrease in gene expression. Value higher than 1 + 1 SD, Value lower than 1 - 1 SD | ||||
Sermeus et al. Molecular Cancer 2008 7:27 doi:10.1186/1476-4598-7-27 |
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