Table 1

β-catenin mutations detected in HCCs. Indicated is the number of the codon affected and the resulting amino acid change as well as the phenotype observed by immunohistochemistry with regard to presence of β-catenin (cytoplasmic/nuclear) and GS-expression (GS).
Patient number
 Codon
 Mutation
 Aminoacid
 β-Cat cytoplasmic
 β-Cat nuclear
 GS
20071/2,3,-00
 33
 TCT > TGT
 S>C
 +
 +
 +
30600/4-05
 35
 ATC>AGC
 I>S
 +
 +
 +
334/2-02
24138/E-01
 36
 CAT>CCT
 H>P
 +
 +
 +
14865/2-05
 37
 TCT>TGT
 S>C
 +
 +
 +
4836/3-05
 37
 TCT>TTT
 S>F
 +
 +
 +
21217-00
 41
 ACC>GCC
 T>A
 +
 +
 +
6700/2.3.-05
 44
 CCT>GCT
 P>A
 +
 -
 +
6700/2.3.-05
29923/B-03
 45
 TCT>CCT
 S>P
 +
 -
 +
28356/2-05
 45
 TCT>TTT
 S>F
 +
 +
 +

Austinat et al. Molecular Cancer 2008 7:21   doi:10.1186/1476-4598-7-21