Synthesis and biologic properties of hydrophilic sapphyrins, a new class of tumor-selective inhibitors of gene expression

doi:10.1186/1476-4598-6-9

Molecular Cancer

Volume 6

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Wang Z
Lecane PS
Thiemann P
Fan Q
Cortez C
Ma X
Tonev D
Miles D
Naumovski L
Miller RA
Magda D
Cho DG
Sessler JL
Pike BL
Yeligar SM
Karaman MW
Hacia JG

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Wang Z
Lecane PS
Thiemann P
Fan Q
Cortez C
Ma X
Tonev D
Miles D
Naumovski L
Miller RA
Magda D
Cho DG
Sessler JL
Pike BL
Yeligar SM
Karaman MW
Hacia JG
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Research

Synthesis and biologic properties of hydrophilic sapphyrins, a new class of tumor-selective inhibitors of gene expression

Zhong Wang¹ , Philip S Lecane¹ , Patricia Thiemann¹ , Qing Fan¹ , Cecilia Cortez¹ , Xuan Ma¹ , Danielle Tonev¹ , Dale Miles¹ , Louie Naumovski¹ , Richard A Miller¹ , Darren Magda¹ , Dong-Gyu Cho² , Jonathan L Sessler² , Brian L Pike³ , Samantha M Yeligar³ , Mazen W Karaman³ and Joseph G Hacia³

¹Pharmacyclics, Inc., Sunnyvale, California, USA

²Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas, USA

³Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California, USA

author email corresponding author email

Molecular Cancer 2007, 6:9doi:10.1186/1476-4598-6-9


Published:	19 January 2007

Additional files

Additional file 1:

Methods and statistical analyses used in these studies. Here we provide Gene Ontology (GO) analyses, the protocol for tissue extraction methodology and supplemental biodistribution analyses, details concerning the synthesis of hydrophilic sapphyrins, and NCI Developmental Therapeutics Program tumor cell line panel data

Format: DOC Size: 2.3MB Download file

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Additional file 2:

Normalized hybridization signal intensity values for all microarray experiments. This file provides all the processed hybridization signals generated in gene expression profiling experiments along with statistical analyses of differentially expressed genes.

Format: TXT Size: 8.4MB Download file

Additional file 3:

Selected gene expression data Part I. Data from all 94 probe tilings showing up-regulation in response to 1.25uM sapphyrin PCI-2050 and down-regulation in response to 5ug/mL actinomycin D

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Additional file 4:

Selected gene expression data Part II. Probe tilings up-regulated by both doses of PCI-2050 but down-regulated by actinomycin D.

Format: XLS Size: 973KB Download file

This file can be viewed with: Microsoft Excel Viewer