Figure 1.

Effect of retinoic acid on the proliferation of human pancreatic cancer cells. All-trans-retinoic acid significantly inhibited the proliferation of CAPAN-2 (top panel) and Hs766T cells (bottom panel), in a concentration and time-dependent manner. Two-way ANOVA: Capan-2: Concentration effect F(3,48) = 46.6; Time effect F(5,48) = 147.8; Interaction F(15,48) = 5.79, all P < 0.0001; Hs766T: Concentration effect F(3,24) = 61.9; Time effect F(5,24) = 86.9; Interaction F(15,24) = 5.92, all P < 0.0001. Cell counts are expressed as percentage of control, bars represent means ± SEM.