Figure 2.

NMR-based isotopomer analysis of intracellular pyrimidine and purine ribose synthesis from glucose. The regions of the 2D TOCSY spectra captured from NHBE, hT/LT and hT/LT/Ras cells including both the pyrimidine and purine riboses were analyzed for relative ¹³C enrichment. The regions of the spectra showing the cross peaks of the nucleotide ribose moieties (H1'-H2' interaction) are shown.