|
Clinical and bio-pathological features of colorectal carcinomas employed in the study. |
||||||
| Feature |
No. |
MSS |
(%) |
MSI-H |
(%) |
P-value* |
|
|
||||||
| Sex |
||||||
| Male |
21 |
15 |
(65.2) |
6 |
(37.5) |
NS |
| Female |
18 |
8 |
(34.8) |
10 |
(62.5) |
|
| Age (years) |
||||||
| <55 |
3 |
2 |
(8.7) |
1 |
(6.3) |
NS |
| 55–70 |
11 |
9 |
(39.1) |
2 |
(12.5) |
|
| >70 |
25 |
12 |
(52.2) |
13 |
(81.3) |
|
| Tumor site |
||||||
| Proximal colon |
18 |
5 |
(21.7) |
13 |
(81.3) |
<0.001 |
| Distal colon |
21 |
18 |
(78.3) |
3 |
(18.7) |
|
| Tumor stage (TNM) |
||||||
| I |
2 |
1 |
(4.3) |
1 |
(6.3) |
NS |
| II |
16 |
9 |
(39.2) |
7 |
(43.8) |
|
| III |
13 |
7 |
(30.4) |
6 |
(37.5) |
|
| IV |
8 |
6 |
(26.1) |
2 |
(12.5) |
|
| Tumor type |
||||||
| Adenocarcinoma |
29 |
22 |
(95.7) |
7 |
(43.7) |
<0.001 |
| Mucinous adenocarcinoma |
10 |
1 |
(4.3) |
9 |
(56.3) |
|
| Grade of differentiation |
||||||
| Well/moderate |
29 |
22 |
(95.7) |
7 |
(43.7) |
<0.001 |
| Poor |
10 |
1 |
(4.3) |
9 |
(56.3) |
|
| MMR protein expression |
||||||
| MLH1 negative |
15 |
0 |
15 |
(93.8) |
<0,001 |
|
| MSH2 negative |
1 |
0 |
1 |
(6.2) |
||
| MLH1/MSH2 positive |
23 |
23 |
(100) |
0 |
||
|
* Evaluated with Chi-square test or the Fisher's Exact test NS, not significant | ||||||
Lanza et al. Molecular Cancer 2007 6:54 doi:10.1186/1476-4598-6-54 |
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