Table 1

Clinical, methylation and CGH data for prostate cancer tissues
Tumor No.
 Stage
 Gleason Score
 Molecular Group
 LINE-1 %hypo
 No. hypem. genes
 Chromosomal losses
 Chromosomal gains
36
 pT3bN0
 7
1
 4
 -
 3q21q26.2
38
 pT2N0
 7
4
 4
 -
 -
50
 pT3bN0
 7
 hypo
 10
 4
 1q31
 6p,7p,16p,17p, 18p,19, 20q13,21,22,Y
65
 pT3bN0
 7
 both
 9
 4
 Y
 1p33p34.3, 2p21p23, 2q14.1q14.3, 2q33q36, 3p14.1p21.3, 3q25.1q26.3, 4q13.3q28, 5q22, 5q31.2q32, 6q16.1q22.1, 8q22.1q23, 10p11.2p13, 10q11.2q22.3, 12q13.2q24.31, 13q21.1q31, 14q21q32.2, 18q11.2q22, Xp21.3q27
83
 pT3bN0
 7
 hypo
 6
 4
 1q31, 2q33q37, 4q31, 13q21q31, 15q24,
 4q12, 5q13, 17p, 18p, 19, Y
89
 pT2bN0
 3
 hypo
 5
 2
 9q33q34, X
 2q11q24, 4q12q22, 6q22, 12p,18p, Y
93
 pT3bN0
 7
4
 4
 -
 Yq
95
 pT3bN1
 10
 hypo
 7
 4
 Xq
 18p, Y
99
 pT2bN0
 5
0
 1
 -
 2q14q24,10q11q21
101
 pT3aN0
 8
 none
 0
 3
 1p36, 14q31q32, 17p, 22
 -
105
 pT3aN0
 5
1
 1
 1p36,2,3,4
 -
107
 pT3aN0
 7
 none
 3
 4
 18p, Y
 4q24, 6q22, Xp11.2p11.4
117
 pT3bN0
 5
3
 4
 -
 1q21q25,2q11q14,19q13
119
 pT3bN1
 9
 none
 1
 3
 7p15pter, 15q23qter, Y
 10q21q22
121
 pT2bN0
 6
 chrom8
 1
 4
 1q32q41, 3p21, 4p15p16, 8p22p23, 9p23p24,10q25q26, 11q23q25, 12q24, 13q32q34, 14q24q32, 15q24q26, 17q24q25, Xp21p22
 Yq
123
 pT2aN0
 5
1
 1
 9q21.2q21.3, 10q26, 16p, Y
 2p14p16, 2q24.3q32.1, 6q14q16.1
125
 pT2bN0
 6
1
 0
 14q31
 -
127
 pT2bN0
 7
 none
 2
 2
 7q36, Yq
 2q22q32.3, 4q11q31.3, 13q14.1q21.1, 14q21q23, 15q21.1q23
133
 pT2bN1
 7
 chrom8
 0
 4
 22, Y
 1q, 2q22q34, 3q11.1q26.1, 4q22q27, 5q21q31, 6q21q24, 8q11q23, 10q11q21.3, 12q21q22, 14q12q22, X
137
 pT2bN0
 8
 chrom8
 1
 1
 16, 17, 18p, 18q11.1q21.1, 19, 21q22, Y
 3q23q26.3, 4q13.2q21.3, 5q, 7q13q31, 8p21pter, 8q24, 9p, 14q13qter
139
 pT3bN1
 9
 chrom8
 1
 4
 19q, Y
 1q25q31, 2q11q33, 3, 4q, 5q13q23, 6q14q25, 7q21qter, 8q13q23, 11q14qter, 13q21q32, 14q11.1q21, 18q12, Xq21.3qter
141
 pT2bN0
 4
 chrom8
 0
 2
 16, 17, 18p, 19, 20, 22, Y
 1q31q32.1, 2, 3q13.3qter, 4q11q31.1, 5q14qter, 6q, 7p12pter, 7q22q31.2, 8q12q21.2, 10q21.1q23.1, 11q14.3qter, 12q14qter, 13q14.1qter
145
 pT4N1
 7
 hypo
 11
 3
 Y
 3q25q27,4q24q26,7q11q22,13q31q34,17p,18p
149
 pT2bN0
 6
2
 2
 Y
 2p, 4p12, 4q24q26, 5q11q13, 7p12, 8q23q24, 9,11q22, 12q12q15, 14q24, 17, 19, 20q13,
151
 pT3aN0
 7
0
 1
 3p13p14
 6p14, Xp21
153
 pT3aN0
 5
2
 1
Xq11.2q13
155
 pT3aN0
 5
5
 4
 19p
 3p25p26, Y
157
 pT2aN0
 8
2
 0
 -
 1q21q31, 2q12q24, 3q, 4q12q21, 5q13q14, 6q14q16, 7q11, 8q12q22, 12q12q13, 18p, Y
161
 pT2bN0
 5
3
 4
 15q22q24, Xq22q25
 -
163
 pT3bN1
 5
 chrom8
 2
 2
 16, 17p, 18p, 20, Y
 1q25qter, 2p11p16, 2q32q34, 3q12, 3q21q27, 4q, 6q15q24, 8q12q21, 8q23q24, 12q13q21, 13q14q32, 14q12q21, 18q, Xq11.1q26
169
 pT3aN0
 7
 chrom8
 3
 2
 16, 17p, 18p, 19, Y
 2, 3, 4q, 5q, 7p15pter, 8q22q24, 13q31qter, 14q24qter, 17q23, 18q21qter, Xq21.3q26
171
 pT2bN0
 5
 hypo
 8
 4
 10q26, 18p. -19, 22, Y
 1p31, 2p12p13, 2q11q34, 4q22q26, 5q22, 6q11q23, 14q22q24, X
175
 pT2bN0
 8
11
 4
 13q14
 -
183
 pT3aN0
 6
19
 4
 1p36,9q34
 -
187
 pT2bN0
 8
 chrom8
 1
 3
 16, 17p, 18p, 19, 21, 22, Y
 1, 2, 3q13qter, 4q, 5q14q33.1, 6q16q23, 7p, 7q22q33, 8q, 11q14.3qter, 12q14qter, 13q21qter, 14q24q31, 15q, Xq22qter
189
 pT2bN0
 7
 none
 0
 4
 3p25p26, 10q26, Xq22qter, Yq
 -
191
 pT2bN0
 7
0
 3
 4q31, 5q31q35, 9q33, 12p12
 -
205
 pT3aN0
 7
5
 1
 18p, 19, 22, Y
 2q31q33, 6q22.3q23, 10q21q22, Xp11.1p11.4, Xq
209
 pT3aN0
 7
 both
 8
 4
 1p36, 8p, 16, 17, 18p, 19, 20, 22, Y
 1q31q32.1, 2q11.1q34, 3, 4q21.1qter, 5q14q31, 6q11q23, 7q21q34, 8q, 9, 11q14q22, 12q15q24, 13q14qter, 18q
213
 pT2aN0
 7
8
 4
 8q24.2qter, 14q32, 16, 17, 18p, 22, Y
 -
215
 pT3aN0
 7
9
 4
 19q13, 22q13,Y
 3q24q26, 5q12, 8p12, 17, 18, Xp11p21, X21q24
217
 pT2bN0
 8
5
 4
 18p13, Y
 2q33q35, 4q13q28,5q21q31,8q21,8q24,12q13, 12q21q23, Xq13q25
219
 pT4N1
 7
 both
 21
 4
 5q34qter, 8p22pter, 19, Yq
 1p22p31.3, 4q21q22, 4q31.1, 5q13, 6q24q26, 7q, 8q21q24, 10q21, 11q14q22, 20q13, Xq13q22
225
 pT3bN0
 6
4
 4
 4q28, 8q24qter, Yq
 -
227
 pT2aN1
 7
3
 4
 22q13
 3q11q21
232
 pT2bN1
 7
 both
 13
 4
 8p22pter
 -
245
 pT3aN0
 7
4
 3
 17p13, 18p
 1p31
247
 pT3bN1
 7
 chrom8
 3
 3
 8p21pter, 9q21, 22, Y
 Xq12
253
 pT3aN1
 7
1
 4
 1p36, 2q33q37, 6p21.3p25, 8p21, 14q31q32, Y
 -
256
 pT3bN0
 7
1
 4
 2p2p21, 6q, 15q26,16p, 18,X
 -

The numbers of the tumors used in the microarray analysis are in bold type, as are hypomethylation values considered significantly elevated (< 4%) and typical chromosome 8 aberrations. All cancers were M0 at the time of prostatectomy. No. hypermethylated genes indicates hypermethylation of APC, GSTP1, RARB2, and RASSF1A. LINE-1 hypomethylation was determined by Southern blot analysis. Chromosomal dosage changes were determined by comparative genomic hybridization.

Schulz et al. Molecular Cancer 2007 6:14   doi:10.1186/1476-4598-6-14