Expression of full-length p53 and its isoform Δp53 in breast carcinomas in relation to mutation status and clinical parameters

doi:10.1186/1476-4598-5-47

Molecular Cancer

Volume 5

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Baumbusch LO
Myhre S
Langerød A
Bergamaschi A
Geisler SB
Lønning PE
Deppert W
Dornreiter I
Børresen-Dale AL

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Baumbusch LO
Myhre S
Langerød A
Bergamaschi A
Geisler SB
Lønning PE
Deppert W
Dornreiter I
Børresen-Dale AL
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Expression of full-length p53 and its isoform Δp53 in breast carcinomas in relation to mutation status and clinical parameters

Lars O Baumbusch¹ , Simen Myhre¹ , Anita Langerød¹ , Anna Bergamaschi¹^,4 , Stephanie B Geisler² , Per E Lønning² , Wolfgang Deppert³ , Irene Dornreiter³ and Anne-Lise Børresen-Dale¹^,4

¹Department of Genetics, Institute for Cancer Research, Rikshospitalet-Radiumhospitalet Medical Center, 0310 Oslo, Norway

²Department of Medicine, Section of Oncology, Haukeland University Hospital, 5021 Bergen, Norway

³Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg, Martinistr. 52, 20251 Hamburg, Germany

⁴Medical Faculty, University of Oslo, Oslo, Norway

author email corresponding author email

Molecular Cancer 2006, 5:47doi:10.1186/1476-4598-5-47


Published:	20 October 2006

Additional files

Additional File 1:

mRNA and aa sequence of p53 and Δp53. p53 mRNA and its translated protein sequence. The untranslated precursor and untranslated region afterwards are illustrated with yellow highlights. Alternating exons are written in consecutive black and blue and translation codon triplets are marked with alternating white and light yellow. The removed alternative splice sequence of Δp53 is shown with light blue colour and the alternative splice cassettes are indicated with red. Sequence information is based on ENSEMBL notification [74].

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Additional File 2:

p53 and Δp53 mutation specifications. This table lists the coded patient sample IDs, mutation classifications for p53 and Δp53 (including codon, nucleotides and aa changes), incidents of flagging primers and the numeric qRT-PCR expression levels.

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Additional File 3:

Relationship between Δp53 status and the standard clinical, pathological and biological factors. The data provided represent the relationship between Δp53 status and the standard clinical, pathological and biological factors.

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