Figure 3.

Some normal tissues show Eag1 staining in restricted populations. In the female reproductive system, the follicular epithelia (a) do not show Eag1-staining. The surface and gland epithelia of the resting endometrium are also negative (b). However, in proliferating and secretory activated glands, a strong Eag1-expression can be observed (b. Inset). In the healthy mammary gland (c), Eag1 signals are limited to luminal cells in the acini and ducts of the ductulo-lobular unit, while the basal cell layer is negative (arrow). In the testis (d), interstitial cells and spermatogonia within the ducti seminiferi show a weak to intermediate Eag1 expression. (e) The gastric corpus mucosa express little or no Eag1 (white arrow) except in chief cells (black arrow) where very strong signals are observed. In colon (f), the normal mucosa is negative, while mucosa-associated lymphocytes stain positive.