|
Frequent copy number and expression altered genes1. |
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| GAINED AND OVEREXPRESSED GENES |
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|
|
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| SYMBOL |
GENE DESCRIPTION |
% |
MEDIAN |
LOCATION |
|
|
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| ATP2B4 |
ATPase, Ca++ transporting, plasma membrane 4 |
20.00 |
1.17 |
1q25-q32 |
| LOC153222 |
Adult retina protein |
25.00 |
1.32 |
5 |
| GBAS |
Glioblastoma amplified sequence |
20.00 |
1.61 |
7p12 |
| GUSB |
Glucuronidase, beta |
20.00 |
1.42 |
7q21.11 |
| RFC2 |
Replication factor C (activator 1) 2, 40kDa |
26.32 |
1.06 |
7q11.23 |
| MCM7 |
MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) |
35.29 |
1.02 |
7q21.3-q22.1 |
| GIMAP6 |
GTPase, IMAP family member 6 |
20.00 |
1.29 |
|
| LR8 |
LR8 protein |
21.05 |
2.34 |
7q36.1 |
| APOE |
Apolipoprotein E |
22.22 |
1.48 |
19q13.2 |
| EMP3 |
Epithelial membrane protein 3 |
33.33 |
1.36 |
19q13.3 |
| FPR1 |
Formyl peptide receptor 1 |
25.00 |
1.94 |
19q13.4 |
|
|
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| LOST AND UNDEREXPRESSED GENES |
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|
|
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| SYMBOL |
GENE DESCRIPTION |
% |
MEDIAN |
LOCATION |
|
|
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| CYP1B1 |
Cytochrome P450, family 1, subfamily B, polypeptide 1 |
21.05 |
-2.87 |
2p21 |
| TDE2 |
Tumor differentially expressed 2 |
23.53 |
-1.86 |
6q22.32 |
| OPTN |
Optineurin |
41.18 |
-1.86 |
10p14 |
| DNAJC12 |
DnaJ (Hsp40) homolog, subfamily C, member 12 |
25.00 |
-1.16 |
10 |
| SIRT1 |
Sirtuin (silent mating type information regulation 2 homolog) 1 |
27.27 |
-1.27 |
10q22.1 |
| PPP3CB |
Protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform |
35.00 |
-2.08 |
10q21-q22 |
| GHITM |
Growth hormone inducible transmembrane protein |
37.50 |
-1.55 |
10q23.2 |
| CYP26A1 |
Cytochrome P450, family 26, subfamily A, polypeptide 1 |
21.05 |
-1.08 |
10q23-q24 |
| LGI1 |
Leucine-rich, glioma inactivated 1 |
45.00 |
-1.32 |
10q24 |
| SLK |
STE20-like kinase (yeast) |
26.32 |
-1.11 |
10q25.1 |
| ADD3 |
Adducin 3 (gamma) |
68.42 |
-1.04 |
10q24.2-q24.3 |
| MXI1 |
MAX interactor 1 |
40.00 |
-1.11 |
10q24-q25 |
| ATRNL1 |
Attractin-like 1 |
30.77 |
-1.65 |
10 |
| KIAA1598 |
KIAA1598 |
21.05 |
-1.83 |
10q26.12 |
| NDFIP2 |
Nedd4 family interacting protein 2 |
33.33 |
-1.22 |
13q22.2 |
| MAP2K4 |
Mitogen-activated protein kinase kinase 4 |
23.53 |
-1.30 |
17p11.2 |
| DSG2 |
Desmoglein 2 |
31.25 |
-1.94 |
18q12.1 |
| TPTE |
Transmembrane phosphatase with tensin homology |
22.22 |
-1.67 |
21p11 |
|
1Percentage of tumors showing copy number and expression alterations (%). Median of expression log2 ratios of copy number altered genes (median). | ||||
Ruano et al. Molecular Cancer 2006 5:39 doi:10.1186/1476-4598-5-39 |
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