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Changes in transcript levels of genes associated with mitotic progression after pRb acute loss |
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| Symbol |
Stat. Value |
Description |
Function |
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| Stmn1 |
11,1 |
stathmin 1 |
microtubule depolymerization mitotic spindle assembly |
| Ckap2 |
8,74 |
cytoskeleton associated protein 2 |
microtubule stabilization |
| Nusap1 |
8,45 |
nucleolar and spindle associated protein 1 |
positive regulation of mitosis |
| Prc1 |
7,06 |
protein regulator of cytokinesis 1 |
mitotic spindle midzone associated-Cdk dependent |
| Ccnf |
6,76 |
cyclin F |
cell cycle, mitosis |
| Ccnb2 |
6,57 |
cyclin B2 |
regulation of cell cycle |
| Anln |
6,18 |
anillin, actin binding protein (scraps homolog, Drosophila) |
cytokinesis |
| Cdc20 |
6,14 |
cell division cycle 20 homolog (S. cerevisiae) |
cytokinesis |
| Smc2l1 |
6,11 |
SMC2 structural maintenance of chromosomes 2-like 1 (yeast) |
mitotic chromosome condensation |
| Ccnb1 |
5,98 |
cyclin B1 |
DNA replication |
| Smc4l1 |
5,91 |
SMC4 structural maintenance of chromosomes 4-like 1 (yeast) |
chromosome segregation and organitation, cytokinesis |
| Plk4 |
5,61 |
polo-like kinase 4 (Drosophila) |
cell cycle and centrosome homeostasis |
| Cdc2a |
5,45 |
cell division cycle 2 homolog A (S. pombe) |
mitotic G2 checkpoint |
| Mdm2 |
5,41 |
transformed mouse 3T3 cell double minute 2 |
traversing start control point of mitotic cell cycle |
| Mki67 |
5,34 |
antigen identified by monoclonal antibody Ki 67 |
meiosis, cell proliferation |
| Rad21 |
5,08 |
RAD21 homolog (S. pombe) |
cytokinesis, DNA repair, apoptosis, mitosis |
| Cdk2 |
5,01 |
cyclin-dependent kinase 2 |
cytokinesis, cell cycle, mitosis |
| Stk6 |
4,95 |
aurora kinase A |
cell cycle and centrosome homeostasis |
| Anapc5 |
4,81 |
anaphase-promoting complex subunit 5 |
cytokinesis, ubiquitin cycle, cell cycle, mitosis |
| Pttg1 |
4,54 |
pituitary tumor-transforming (securin) |
cell cycle, chromosome segregation, mitosis |
| Plk1 |
4,44 |
polo-like kinase 1 (Drosophila) |
cell cycle and centrosome homeostasis |
| Mad2l1 |
4,38 |
MAD2 (mitotic arrest deficient, homolog)-like 1 (yeast) |
mitotic sister chromatid segregation, cytokinesis, mitotic spindle checkpoint |
| Cks2 |
4,15 |
CDC28 protein kinase regulatory subunit 2 |
cytokinesis, cell cycle |
| Rbbp4 |
4,11 |
retinoblastoma binding protein 4 |
transcription |
| Ccna2 |
3,94 |
cyclin A2 |
regulation of cell cycle, cytokinesis |
| Nek2 |
3,7 |
NIMA (never in mitosis gene a)-related expressed kinase 2 |
mitotic sister chromatid segregation, cytokinesis, mitosis |
| Ccne1 |
3,11 |
cyclin E1 |
regulation of progression through cell cycle, DNA replication |
| Brca1 |
2,52 |
Breast Cancer Associated Protein 1 |
DNA repair, apoptosis, mitosis |
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Genes are listed by symbol, change in expression level, description and biological function. | |||
Iovino et al. Molecular Cancer 2006 5:38 doi:10.1186/1476-4598-5-38 |
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