Table 4

Expression in Islands frequently deleted in CRC.

chromosomal region

fraction of patients with deletions

congruent with our expression data

CGH study


1p

yes

[17]

1p36.2-1p36.1

21%

yes

[22]

1p21-1p22

72%

no

[21, 24]

3p12

66%

no

[21, 24]

4

yes

[15, 17, 18]

4p

42%

yes

[19]

4p14

87%

yes

[21, 24]

4q

58%

yes

[19]

4q27-4q28

96%

no

[21, 24]

4q31.3

39%

no

[22]

4q34.3

38%

yes

[25]

4q35

34%

yes

[22]

5q

> 35%

yes

[17, 23]

5q21

81%

yes

[21, 24]

6q16-6q21

72%

no

[21, 24]

8p

37%

no

[17, 18, 23, 25]

8p24-8p21

66%

no

[21, 24]

9p21

64%

yes

[21, 24]

9p22

25%

no

[22]

10q26.2

22%

no

[25]

11q13.1

30%

no

[25]

14q

yes

[17]

14q13-14q21

64%

yes

[21, 24]

15q

yes

[17]

17p

46%

yes

[23]

17p13.2

51%

yes

[25]

17p12

32%

yes

[25]

18

yes

[17]

18p

49%

yes

[23]

18q

60%

yes

[23]

18q

32%

yes

[18, 25]

18q

92%

yes

[19]

18q11.2

72%

no

[22]

18q12.2

59%

no

[25]

18q21-18q23

96%

yes

[21]

18q21.1

60%

yes

[25]

21q

> 35%

yes

[23]

21q21

74%

no

[21, 24]


Literature survey of chromosomal regions with evidence for deletions in colorectal cancers. We checked all regions of frequent chromosomal deletions for congruence with expression patterns. Congruence between literature CGH data and our expression data was declared on the presumption that allelic loss causes mRNA down-regulation.

Staub et al. Molecular Cancer 2006 5:37   doi:10.1186/1476-4598-5-37

Open Data