Table 3

Expression in Islands frequently amplified in CRC.

chromosomal region

fraction of patients

congruence with our expression data

CGH study


1

no

[18]

1q21

57%

no

[21]

3p25.2

30%

yes

[25]

3q26.31

32%

no

[25]

6p12.1

24%

no

[25]

7

46%

yes

[17, 18, 25]

7p

> 35%

yes

[23]

7p

42%

yes

[19]

7p22.3

57%

yes

[25]

7q

42%

yes

[19]

7q

> 35%

yes

[23]

7q11.2-7q12

75%

7q11.23-7q21.3

[21, 24]

8q

yes

[17]

8q

27%

yes

[18, 25]

8q

42%

yes

[23]

8q24

57%

yes

[21]

8q24.21

40%

yes

[25]

8q24.22

30%

yes

[25]

8q24.3

51%

yes

[25]

9q34

67%

9q31.11

[21, 24]

11q

> 35%

yes

[23]

12p13.1-12p13.2

22%

down at 12p13.31-12p13-2

[25]

13

yes

[18]

13

46%

yes

[25]

13q

yes

[17]

13q13

64%

no

[21, 24]

13q34

64%

no

[21]

15q22-15q23

down at 15q21.1-15q22.31

[22]

16p12-11

70%

down at 16p12.1-16p11.2

[21, 24]

16p13.3

49%

no

[25]

16q23.2

24%

no

[25]

17q

42%

yes

[19]

17q12-17q21

yes

[24]

17q12

22%

no

[25]

17q21

59%

yes

[21]

17q21.32

24%

yes

[25]

17q25.3

43%

no

[25]

19p13

70%

yes

[21, 24]

20

yes

[18, 25]

20p

58%

yes

[19]

20q

yes

[17]

20q

65%

yes

[23]

20q

100%

yes

[21]

20q

92%

yes

[19]

20q13.3

56%

yes

[22]

20q13.3

81%

yes

[25]

20q11.2-20q13.2

yes

[24]

22q11

61%

22q11.21-22q21.1

[21]

22q13.2

24%

no

[25]


Literature survey of chromosomal regions with evidence for amplifications in colorectal cancers. We checked all regions of frequent chromosomal amplifications for congruence with expression patterns. Congruence between literature CGH data and our expression data was declared on the presumption that allelic gain causes mRNA up-regulation.

Staub et al. Molecular Cancer 2006 5:37   doi:10.1186/1476-4598-5-37

Open Data