Figure 3.

Effect of XIAP loss on Doxorubicin sensitivity in canine cell-lines. The effect on viability is shown for BDE cells in (A), for P114 cells in (B), and for D17 cells in (C). Control (▲); 50 nM XIAP siRNA (◇); 50 nM Nonsense siRNA (■). Data is represented as percentage viability towards untreated control. Points represent average of four independent experiments (n = 4). significance of differences in viability of the XIAP siRNA treated cell-lines at different drug concentrations compared to control and nonsense were determined by an one-way ANOVA using the Dunnett multiple comparisons test (*P < 0.05).