|
Clinicopathological and molecular features of BRAF mutant colorectal cancers stratified according to microsatellite instability status. |
||||||
| MSI- |
MSI+ |
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|
|
|
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| Feature |
BRAF WT (n = 192) (%) |
BRAF M (n = 9) (%) |
P |
BRAF WT (n = 19) (%) |
BRAF M (n = 12) (%) |
P |
|
|
||||||
| Age (years) |
68.5 ± 12.6 |
58.2 ± 26.5 |
NS |
67.5 ± 16.8 |
76.1 ± 10.9 |
NS |
| Females |
39 |
44 |
NS |
63 |
75 |
NS |
| TILS + a |
3 |
44 |
0.0004 |
28 |
60 |
0.08 |
| Node negative |
62 |
62 |
NS |
81 |
89 |
NS |
| Proximal site |
36 |
67 |
0.05 |
72 |
89 |
NS |
| Poor grade |
15 |
40 |
0.12 |
25 |
56 |
0.11 |
| Mucinous |
12 |
53 |
0.05 |
6 |
44 |
0.04 |
| CIMP+ |
15 |
50 |
0.03 |
40 |
88 |
0.03 |
| Dist. MLH1 methylated |
7 |
12 |
NS |
40 |
75 |
0.10 |
| Prox. MLH1 methylated |
1 |
0 |
NS |
33 |
75 |
0.06 |
| KRAS mutant |
43 |
0 |
0.008 |
21 |
0 |
0.12 |
| TP53 mutant |
29 |
11 |
NS |
5 |
18 |
NS |
|
aTumor-infiltrating lymphocytes | ||||||
Qi Li et al. Molecular Cancer 2006 5:2 doi:10.1186/1476-4598-5-2 |
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