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Associations between BRAF mutation and molecular features of colorectal cancer. |
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| Feature (n) a |
BRAF wild-type (%) |
BRAF mutation (%) |
P |
|
|
|||
| Total (275) |
252 (92) |
23 (8) |
|
| MSI |
|||
| negative (204) |
195 (96) |
9 (4) |
|
| positive (31) |
19 (61) |
12 (39) |
<0.0001 |
| Methylation status |
|||
| CIMP- (150) |
145 (97) |
5 (3) |
|
| CIMP+ (42) |
31 (74) |
11 (26) |
<0.0001 |
| MLH1 distal region |
|||
| Negative (168) |
159 (95) |
9 (5) |
|
| Positive (24) |
17 (71) |
7 (29) |
<0.0001 |
| MLH1 proximal region |
|||
| Negative (179) |
169 (94) |
10 (6) |
|
| Positive (13) |
7 (54) |
6 (46) |
<0.0001 |
| KRAS |
|||
| Wild-type (156) |
134 (86) |
22 (14) |
|
| Mutant (93) |
93 (100) |
0 (0) |
<0.0001 |
| TP53 |
|||
| Wild-type (183) |
166 (91) |
17 (9) |
|
| Mutant (66) |
62 (94) |
4 (6) |
NS |
|
a Data was unavailable for MSI status in 40 cases, methylation status in 83 cases, KRAS mutation in 26 cases and TP53 mutation in 26 cases | |||
Qi Li et al. Molecular Cancer 2006 5:2 doi:10.1186/1476-4598-5-2 |
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