|
Down-regulated genes in rats fed with SPI diet* |
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| Category and Gene Name |
Probe Set GB Accession No. |
Fold Change |
P value |
|
|
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| Cell adhesion |
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| Embigin |
AJ009698 |
-5.13 |
0.001 |
| Cell Cycle/growth control |
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| FGF receptor activating protein 1 |
U57715 |
-5.59 |
0.002 |
| BEST5 protein |
Y07704 |
-2.37 |
0.003 |
| Peptide tyrosine-tyrosine (YY) |
M17523 |
-3.91 |
0.002 |
| Glucagon gene |
K02813 |
-6.58 |
0.002 |
| Epithelial membrane protein-1 |
Z54212 |
-3.47 |
0.017 |
| Neu oncogene |
X03362 |
-1.58 |
0.05 |
| Defense/immunity protein |
|||
| Beta defensin-1 |
AF068860 |
-42.16 |
0.001 |
| AF093536 |
-10.2 |
0 |
|
| Detoxification/antioxidation |
|||
| Glutathione S-transferase |
J02810 |
-7.14 |
0 |
| Glutathione S-transferase Yb |
X04229 |
-11.71 |
0.001 |
| Glutathione S-transferase, alpha 1 |
K01932 |
-4.18 |
0.004 |
| Glutathione S-transferase Yc1 |
S72505 |
-5.23 |
0.001 |
| Glutathione S-transferase Yc2 |
S72506 |
-5.27 |
0.012 |
| S82820 |
-3.45 |
0.006 |
|
| Cytochrome P450 4F4 (CYP4F4) |
U39206 |
-6.52 |
0.002 |
| Cytochrome P450CMF1b |
J02869 |
-4.12 |
0.002 |
| Cytochrome P450 (CYP4F1) |
M94548 |
-2.88 |
0.002 |
| 1-Cys peroxiredoxin |
Y17295 |
-2.55 |
0.002 |
| Metallothionein |
M11794 |
-2.92 |
0.006 |
| D-amino-acid oxidase |
AB003400 |
-5.42 |
0 |
| Peroxiredoxin 6 |
AF014009 |
-3.07 |
0.008 |
| Phenylalanine hydroxylase |
M12337 |
-10.99 |
0.001 |
| Metabolism |
|||
| Dipeptidase |
L07315 |
-3.08 |
0.001 |
| Meprin beta-subunit |
M88601 |
-3.27 |
0.001 |
| Disintegrin and metalloprotease domain 7 |
X66140 |
-14.03 |
0 |
| Ligand binding/carrier |
|||
| Carnitine transporter |
AB017260 |
-3.81 |
0.003 |
| Chloride channel (ClC-2) |
AF005720 |
-3.26 |
0.001 |
| Putative potassium channel |
AF022819 |
-2.69 |
0.001 |
| Mitochondrial dicarboxylate carrier |
AJ223355 |
-2.54 |
0.01 |
| Aquaporin 3 |
D17695 |
-4.13 |
0 |
| Intestinal fatty acid binding protein |
K01180 |
-4.43 |
0.005 |
| Na_H_Exchanger |
L11236 |
-4.47 |
0.002 |
| H+, K+-ATPase |
M90398 |
-2.52 |
0.001 |
| Carbonic anhydrase IV |
S68245 |
-4.28 |
0.005 |
| Sodium transporter |
X59677 |
-3.4 |
0 |
| Phosphatidylethanolamine binding protein |
X75253 |
-2.69 |
0 |
| Signal transduction |
|||
| B7 antigen |
X76697 |
-170.95 |
0.002 |
| HCNP |
E05646 |
-3.38 |
0 |
| Itmap1 |
AF022147 |
-7.97 |
0.005 |
| Guanylate cyclase activator 2A |
M95493 |
-3.28 |
0.006 |
| Sgk |
L01624 |
-2.76 |
0 |
| Stress response/apoptosis |
|||
| Prostaglandin D synthetase |
J04488 |
-45.8 |
0.01 |
| Structure proteins |
|||
| Muc3 |
U76551 |
-3.56 |
0.01 |
| Intestinal mucin |
M76740 |
-3.31 |
0.006 |
| Mucin-like protein |
M81920 |
-3 |
0 |
| Plasmolipin |
Z49858 |
-2.92 |
0.003 |
| Transcription factor/regulator |
|||
| Testis specific X-linked gene |
X99797 |
-6.91 |
0.003 |
| Others |
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| Arginase II |
U90887 |
-3.22 |
0 |
| 3-phosphoglycerate dehydrogenase |
X97772 |
-4.15 |
0.017 |
| Aldehyde dehydrogenase family 1 |
AF001898 |
-3.93 |
0.004 |
|
*Changes in gene expression were determined by t-test (DMT), comparative analysis (MAS 5.0), and SAM (Stanford). Gene expression profiles from CAS animals were used as control. P value and fold-change are based on the DMT analysis; whereas genes listed above met all of the analytical criteria as described in Methods. | |||
Xiao et al. Molecular Cancer 2005 4:1 doi:10.1186/1476-4598-4-1 |
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