Figure 3.

Schematic representation of randomly amplified polymorphic DNA PCR analysis of tumor DNA. Panel A shows chromosome with multiple binding sites for selected primers (red arrows). Panel B is a representation of a given locus in six different patients. Patient 1 contains both primer sites, patients 2, 4, and 5 contain neither sites, and patients 3 and 6 contain only one of the primer sites. Solid line represents normal chromosome, while the dotted line represents regions of chromosomal loss. Panel C displays the DNA fingerprints for paired normal and tumor DNA from these six individuals. The blue bands correspond to fragments indicated in Panel B.