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The relationship between diabetes and pancreatic cancer

Feng Wang1, Margery Herrington12, Jörgen Larsson1 and Johan Permert1*

Author Affiliations

1 Surgery Department, Karolinska Institute at Huddinge University Hospital, 141 86 Stockholm, Sweden

2 Department of Biology, Adams State College, Alamosa, CO 81102, USA

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Molecular Cancer 2003, 2:4  doi:10.1186/1476-4598-2-4

Published: 6 January 2003


About 80% of pancreatic cancer patients have glucose intolerance or frank diabetes. This observation has led to the following two hypotheses: i. pancreatic cancer causes the associated diabetes and ii. the conditions associated with diabetes promote the development of pancreatic cancer. Evidence supporting both hypotheses has been accumulated in previous studies. This article reviews these studies, especially those that have been conducted recently.