Table 2

Correlation of promoter methylation with clinical and histologic parametrs, HPV status and microsatellite instability in CC patients

Methylated genes


Parameter

Overall

CDH1

DAPK

RARB

HIC1

FHIT

RASSF1A

APC

CDKN2A

MGMT

BRCA1


Histology

SCC (N = 77)

66

45

36

24

12

9

5

5

6

4

3

AC (N = 5)

5

0

1

0

3

0

1

4

1

0

2

Significance

P = 1.00

P = 0.02

P = 0.372

P = 0.315

P = 0.040

P = 1.00

P = 0.323

P = 0.0003

P = 0.367

P = 1.00

P = 0.028

Stage

I (N = 17)

10

6

5

3

5

0

4

2

2

0

0

II (N = 19)

19

13

12

5

3

3

2

2

1

0

2

III-IV (N = 46)

42

16

20

16

7

6

0

5

4

4

3

Significance

P = 0.0005

P = 0.0005

P = 0.129

P = 0.394

P = 0.460

P = 0.279

P = 0.003

P = 1.00

P = 0.759

P = 0.395

P = 0.397

Size of tumor

1–5 cm (N = 32)

28

20

13

10

8

3

4

4

1

0

1

≥ 6 cm (N = 38)

34

21

19

13

6

4

1

3

4

2

2

Significance

P = 1.000

P = 0.540

P = 0.433

P = 0.793

P = 0.337

P = 1.00

P = 0.171

P = 0.695

P = 0.366

P = 0.497

P = 1.000

Age (yrs)

≤ 40 (N = 32)

28

17

17

12

6

6

1

1

3

3

1

41–50 (N = 17)

12

8

5

5

3

0

2

0

1

1

1

51–60 (N = 13)

13

6

5

6

3

2

1

6

1

0

3

> 60 (N = 20)

18

14

10

1

3

1

2

2

2

0

0

Significance

P = 0.113

P = 0.439

P = 0.400

P = 0.021

P = 0.956

P = 0.169

P = 0.600

P = 0.0004

P = 1.000

P = 0.467

P = 0.053

Clinical Outcome

Alive (N= 39)

30

18

19

8

7

3

5

4

2

0

0

DOC (N= 43)

41

27

18

16

8

6

1

5

5

4

5

Significance

0.015

P = 0.131

P = 0.533

P = 0.097

P = 0.939

P = 0.487

P = 0.097

P = 1.000

P = 0.436

P = 0.118

P = 0.056

Treatment response¶

CR (N= 21)

19

11

15

3

4

1

2

3

2

0

0

DOC/PR (N = 26)

24

15

10

12

4

3

1

4

3

2

2

Significance

1.000

0.716

0.024

0.020

1.000

0.617

0.579

1.000

1.000

0.495

0.495

HPV type

HPV 16 (N = 47)

42

27

24

15

9

6

4

5

3

3

2

HPV 18 (N = 6)

5

2

1

1

2

0

1

1

1

0

1

Multiple (N = 11)

8

7

3

2

1

0

0

2

2

0

1

Others (N = 16)

12

9

8

5

2

3

0

0

1

1

1

significance

P = 0.543

P = 0.740

P = 0.280

P = 0.792

P = 0.560

P = 0.467

P = 0.365

P = 0.288

P = 0.327

P = 1.000

P = 0.412

MSI

MSS (N = 30)

26

20

17

4

2

3

1

2

5

4

2

MSI-L (N = 9)

9

6

4

2

1

2

1

0

1

0

2

MSI-H (N = 9)

8

2

3

3

4

0

1

3

1

0

1

Significance

P = 0.516

P = 0.065

P = 0.513

P = 0.434

P = 0.023

P = 1.000

P = 0.313

P = 0.079

P = 1.000

P = 0.443

P = 0.266


P value corresponds to the P value from the Fisher's Exact test for the first two rows and for the P value from the Analysis of Variance for the last 3 rows. ¶Only patients with at least 5 months follow-up and treatment were considered and patients with treatment unknown or no treatment were excluded. SCC, squamous cell carcinoma; AC, adenocarcinoma; MSS, microsatellite stable; MSI-L, microsatellite instability low; MSI-H, microsatellite instability high; DOC, died of cancer; PR, partial response

Narayan et al. Molecular Cancer 2003 2:24   doi:10.1186/1476-4598-2-24

Open Data