Email updates

Keep up to date with the latest news and content from Molecular Cancer and BioMed Central.

Open Access Highly Accessed Research

Estrogen promotes stemness and invasiveness of ER-positive breast cancer cells through Gli1 activation

Ying Sun, Yunshan Wang, Cong Fan, Peng Gao, Xiuwen Wang*, Guangwei Wei* and Junmin Wei*

Molecular Cancer 2014, 13:137  doi:10.1186/1476-4598-13-137

PubMed Commons is an experimental system of commenting on PubMed abstracts, introduced in October 2013. Comments are displayed on the abstract page, but during the initial closed pilot, only registered users can read or post comments. Any researcher who is listed as an author of an article indexed by PubMed is entitled to participate in the pilot. If you would like to participate and need an invitation, please email, giving the PubMed ID of an article on which you are an author. For more information, see the PubMed Commons FAQ.

ER-Gli1-ALDH1 axis in TNBC

Go Yoshida   (2014-07-09 09:40)  School of Medicine, Keio University

Estrogen receptor (ER) expression was reported to be positively correlated with glioma-associated oncogene homoglog 1 (Gli1) and ALDH1 both in vitro and in vivo. The authors mentioned in Discussion that triple-negative breast cancers (TNBCs) include a large number of CD44 (+) /CD24 (-) cancer stem cell, although ER-Gli1-ALDH1 axis does not exist. In contrast, there is a report that the Gli1 expression in TNBCs was significantly higher than in breast cancers other than TNBCs (Oncol Lett. 2011 Sep 1;2(5):995-1001.). That is why ER is likely to activate non-canonical Shh signaliing pathway.

Competing interests

No Competing Interests Exist.


Post a comment