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Estrogen promotes stemness and invasiveness of ER-positive breast cancer cells through Gli1 activation

Ying Sun, Yunshan Wang, Cong Fan, Peng Gao, Xiuwen Wang*, Guangwei Wei* and Junmin Wei*

Molecular Cancer 2014, 13:137  doi:10.1186/1476-4598-13-137

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ER-Gli1-ALDH1 axis in TNBC

Go Yoshida   (2014-07-09 09:40)  School of Medicine, Keio University

Estrogen receptor (ER) expression was reported to be positively correlated with glioma-associated oncogene homoglog 1 (Gli1) and ALDH1 both in vitro and in vivo. The authors mentioned in Discussion that triple-negative breast cancers (TNBCs) include a large number of CD44 (+) /CD24 (-) cancer stem cell, although ER-Gli1-ALDH1 axis does not exist. In contrast, there is a report that the Gli1 expression in TNBCs was significantly higher than in breast cancers other than TNBCs (Oncol Lett. 2011 Sep 1;2(5):995-1001.). That is why ER is likely to activate non-canonical Shh signaliing pathway.

Competing interests

No Competing Interests Exist.

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