Figure 1.

In GBM with intrinsic resistance, both CSC in the tumor bulk and invading CSC give rise to tumor recurrences after treatment. In GBM with extrinsic resistance, CSC in the tumor bulk were depleted and recurrences were formed by invading CSC that were protected in the brain parenchyma.

Beier et al. Molecular Cancer 2011 10:128   doi:10.1186/1476-4598-10-128
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